EGFR and cancer: Various cancer-related signaling pathways and molecules have been reported to be regulated by EGCG, such as blocking the cell cycle in G0–G1 phase [66,67] and inducing cancer cell apoptosis [44,46], suppressing the activity of ERK1/2 [17] and mitogen activation protein kinases (MAPKs) [23,68,69], EGFR phosphorylation [56], activator protein-1(AP-1) [70], DNMT [50] and cell transformation [71,72].