There was an animal study showing that administration of EGCG (4 mg/kg) in N-nitrosomethylbenzylamine (NMBA)- induced EC rats decreased the expression of genes COX-2 and cyclin D1, leading to the reduction of the PGE-2 production [47], indicating that EGCG may exert anti-tumor effects through regulating COX-2 and cyclin D1. The gene discussed is CCND1; the disease is neoplasm.