DNMT1 and neoplasm: Treating with EGCG (5–50 μM, for 12–144 h) on human EC cells (KYSE 510) was able to suppress DNMT1 activity, leading to concentration- and time-dependent reversal of hyper-methylation and reactivation of several tumor methylation-silenced genes (p16, RARβ, hMLH1 and MGMT) [50].