Therefore, it is possible that curcumin, in addition to inhibiting PHGDH directly by binding to its NAD+ pocket [116], hinders its activity indirectly by down-regulating expression of NAMPT (also known as visfatin) as has been demonstrated in breast cancer cell lines (MDA-MB-231, MDA-MB-468, and MCF-7) [124]. This evidence concerns the gene PHGDH and breast cancer.