A recently published paper [119] on in situ proteomic profiling of curcumin targets in HCT116 colon cancer cell line, reports a list of 197 curcumin-binding proteins, among which are many cancer-related metabolic enzymes: GAPDH (Glyceraldehyde 3-Phosphate Dehydrogenase), PKM isozymes M1/M2, LDHA (L-Lactate Dehydrogenase A), MDH1/2 (cytoplasmic/mitochondrial Malate Dehydrogenase), SHMT2 (Serine Hydroxymethyltransferase; mitochondrial), ADP/ATP translocase 1. This evidence concerns the gene GAPDH and malignant colon neoplasm.