In the more specific case of organelle autophagy involving damaged mitochondria, or mitophagy, a well-known mechanism of action is dependent on two gene products, mutations of which predispose an individual to familial Parkinson’s disease (PD), namely PTEN-induced kinase 1 (PINK1) protein kinase and the Parkin E3 ubiquitin ligase [21,22]. Here, PRKN is linked to Parkinson disease.