We therefore retrieved the contribution of the 30 published mutational signatures for each TCGA tumour sample from mSignatureDB [48] and uncovered three of them positively associated with CA20: signature 3, associated with BRCA1/2 mutations; signature 13, attributed to APOBEC activity; and signature 4, characteristic of smoking’s mutational pattern (FDR < 0.05; S11 Fig). The gene discussed is BRCA1; the disease is neoplasm.