TP53 and cancer: TP53 shows the strongest association (linear regression p-value < 0.0001; Fig 4a), with positive correlations for the majority of cancer types surveyed (10 out of 17 cancer types with at least 20 mutated samples; FDR < 0.05; Fig 4b), therefore putatively extending the reported association between loss of p53 and CA [6,7,35] to 10 different cancer types.