Increasing evidence shows that the pathogenesis of IBD is associated with immunological abnormalities.[4,5,18] TFH cells, as a specific subset of CD4+ T helper cells, play an important role in immune balance.[11] TFH cells are involved in the pathogenesis of common autoimmune diseases;[15] however, study about TFH cells in UC disease is lacking. This evidence concerns the gene CD4 and inflammatory bowel disease.