Although serum OPG and TRAIL levels appeared to be regulated in vascular diseases but not in diabetes (Figs. 1 and 2), it is hard to exclude the possibility of a relationship between serum OPG and TRAIL levels and diabetes because serum OPG was significantly regulated in the “ABI below 0.9 and DM” group (Fig. 1). This evidence concerns the gene TNFSF10 and diabetes mellitus.