According to previous reports, OPG is indicated to be associated with ongoing vascular disease, which is common in diabetes, and vascular calcification in the greater arteries has been observed in OPG-deficient mice.[14,16] Additionally, TRAIL has been associated with diabetes in previous reports.[23,24] Therefore, we hypothesized that serum OPG and TRAIL levels are differentially regulated according to the calcified lesion. Here, TNFRSF11B is linked to diabetes mellitus.