Although previous reports have suggested that OPG deficiency is related to aortic vascular calcification and that circulating OPG is upregulated in diabetes and vascular disease, the regulation mechanism of OPG is still unclear.[9,14–16] Therefore, in this study, we aimed to clarify the relationship between OPG and TRAIL levels in vascular calcification and diabetes. Here, TNFRSF11B is linked to diabetes mellitus.