CTLA4 and melanoma: In contrast to anti-CTLA-4 monotherapy, the use of anti-PD-1 pembrolizumab monotherapy (10 mg/kg every 2 weeks for up to 2 years, followed by 2 mg/kg every 3 weeks) for asymptomatic melanoma BMs (n = 23) was associated with a 2-year OS rate of 48% and median OS of 17.0 months (NCT02085070) [5].