PSIP1 and esophageal squamous cell carcinoma: These results were consistent with Singh DK's findings that p21 expression was obviously down‐regulated in LEDGF/p75‐depleted breast cancer cells.37 Our findings strongly supported the idea that LEDGF/p75 regulated p21 expression in ESCC cells through interacting with STRE element implicated in rs2395655 G allele.