LEDGF/p75 is a survival factor that enhances growth and resistance to cell death induced by various environmental stress signals and regulates downstream response pathways by enhancing expression through binding to specific cis‐acting elements, namely, STRE and HSE (heat shock element), located in the promoter region of numerous genes, including antioxidant protein 2, Hsp27, alphaB‐crystallin, and VEGF‐C.24, 30, 31 In addition, LEDGF/p75 has emerged as an important cellular cofactor implicated in multiple pathways affecting cancer progression. The gene discussed is PRDX6; the disease is cancer.