MITF and Werner syndrome: Mutations in the Microphthalmia-associated Transcription Factor (MITF) gene, mapped to chromosome 3p13, result in Type II WS (WS2), which is similar to WS1 apart from dystopia canthorum, and those with WS2 are more often deaf but do not present with abnormally small eyes as seen in the microphthalmia disorder itself which is often times not inherited and do not involve the genes contributing to WS18.