VanderLaan et al56 found that the adoptive transfer of splenocytes from Vα4 transgenic mice into Ldlr−/− Rag1−/− enhanced atherosclerosis in the aortic root, yet when the transgenic mice were crossed with Ldlr−/− mice, the increase in lesion area was seen in the innominate artery rather than the aortic root. This evidence concerns the gene LDLR and atherosclerosis.