FGFR3 and neoplasm: Similarly, of the 14,800 tumors prospectively sequenced at our institution, the 23 samples with FGFR3 R248C mutations, including 20 UCs and three other tumors, had a significantly higher median number of somatic mutations compared with that in the 84 patients with FGFR3 S249C mutations across all tumor types (22; IQR, 8-53 v nine; IQR, 6-11.8; P < .006).