NCAM2 and Waldenstrom macroglobulinemia: We noted a significant interaction between a class II HDAC family member, HDAC9 and neural cell adhesion molecule 2, NCAM2. Deregulation of HDAC9 in cells of lymphoid lineage is believed to induce B-cell lymphoproliferative disorders including Waldenström macroglobulinemia and is associated with general poor prognosis in cancer37,38.