In addition, as an elegant solution to the paucity of NSCLC cell lines harboring endogenous EGFR exon 20 insertion mutations, the authors employed transcription activator-like effector nuclease (TALEN) mutagenesis to generate a suitable model derived from the H1975 EGFR L858R/T790M mutant NSCLC cell line. Here, EGFR is linked to non-small cell lung carcinoma.