Recent studies have shown that alpha 1, 2 fucosyltransferase induces angiogenesis by activating ERK1/2, promotes metastasis by increasing MMP-2 and MMP-9, and accelerates hepatocellular carcinoma progression by influencing Notch signaling and multidrug resistance by inducing PI3K/Akt signaling pathway20–23. The gene discussed is FUT2; the disease is hepatocellular carcinoma.