For instance, FUT1 overexpression in HT-29/M3 colon cancer cells induces synthesis of H type 2 and Ley and decrease in sLex, which results in altered glycosylation patterns of MUC1 and MUC5AC apomucins with reduced interaction with E-selectin, leading to greater invasive and metastatic capacities12–14. This evidence concerns the gene FUT1 and malignant colon neoplasm.