CEP128 and congenital heart disease: SNPs in the Cep128 gene corresponding to the rupture-associated QTL on Chr 12 suggest a possible molecular determinant of myocardial wall strength, as the role of cilia in heart development and congenital heart disease is well established.37,47,48 Primary cilia and ciliogenesis are also required for cell migration essential for organogenesis and tissue repair.49,50 Destabilization of the actin cytoskeleton has been recognized as a dominant inducer of ciliogenesis51 and roles of cilia in mechanotransduction are reviewed in ref. 52.