Myo18b has been implicated in sarcomere assembly and maintenance of myofibril structure38 as well as human skeletal and cardiomyopathies when mutated.39,40 In addition, a polymorphism in Sez6l has been associated with ischemic heart disease in humans41 and five SNPs in Sez6l are significantly associated with the LVD trait. This evidence concerns the gene SEZ6L and coronary artery disorder.