In spite of the fact that cancer outcome is a much more complex phenotype than the proliferation of a cell line, when genes in Table 4 are inhibited in the cancer dependency experiment56 a reduction in the proliferation was observed for ten out of the eleven predicted optimal KOs (HSD17B12, TECR, SC5D, EBP, DHCR24, LSS, NSDHL, CYP51A1, HSD17B7, DHCR7) (see Fig. 3). The gene discussed is CYP51A1; the disease is cancer.