LSS and cancer: In spite of the fact that cancer outcome is a much more complex phenotype than the proliferation of a cell line, when genes in Table 4 are inhibited in the cancer dependency experiment56 a reduction in the proliferation was observed for ten out of the eleven predicted optimal KOs (HSD17B12, TECR, SC5D, EBP, DHCR24, LSS, NSDHL, CYP51A1, HSD17B7, DHCR7) (see Fig. 3).