According to previous research, miR-339-5p inhibited the expressions of the proinflammatory factors IL-6, IL-1β, and TNF-α by abolishing NF-κB activity [22] and miR-361-5p is downregulated in interferon-positive antiphospholipid syndrome and systemic lupus erythematosus dendritic cells [23]. The gene discussed is NFKB1; the disease is systemic lupus erythematosus.