Fu et al. found that oral administration of RN (50 mg/kg/day for 3-4 weeks) restored the impaired long-term potentiation in the hippocampus of APP/PS1 transgenic mice [17], while Xian et al. showed that oral administration of IRN (20 or 40 mg/kg for 3 weeks) ameliorated cognitive deficits induced by Aβ25-35 in rats [15]. This evidence concerns the gene APP and Cognitive impairment.