Our results also demonstrated that CASP3 can be regulated by acacetin (MOL001689) from PHP, oleanolic acid (MOL000263) from RMB and HDW, and kaempferol (MOL000422) from HMM. In the Ras and FoxO pathways, the Fas ligand (FasL) that belongs to the TNF family leads to apoptosis upon binding to its receptor and significantly influences the progression of cancer [62]. This evidence concerns the gene CASP3 and cancer.