CD274 and neoplasm: This molecule has PI3Kα and BRD4 activity which blocks tumor growth by inducing apoptosis and cell cycle arrest, suppressing PDL1 expression on tumor cells; and simultaneously this molecule blocks myeloid cell-derived immunosuppression and provides a durable antitumor immune response in various tumor models due to its potent PI3Kγ and PI3Kδ activity.