CD274 and melanoma: The role of pembrolizumab in patients without neurologic symptoms, perilesional edema, leptomeningeal disease, or the need for corticosteroids, with at least one untreated or progressive BM between 5 and 20 mm, has been addressed in phase II trial that enrolled 18 melanoma and 34 PD-L1 positive NSCLC patients without previous treatment with anti-PD-1/PD-L1 agents.