Some GLA missense variants (p.P60L, p.E66Q, p.R118C, p.A143T and p.I198T) have been described as causative for FD when first discovered in subsequent clinical, functional and population studies (van der Tol et al., 2014; Ferreira et al., 2015; Smid et al., 2015; Lenders et al., 2016). Here, GLA is linked to Fabry disease.