GAL and Fabry disease: Fabry disease (OMIM #301500, FD) is a rare X-linked recessive hereditary systemic disorder of glycosphingolipid metabolism, caused by total or partial decreased activity of alpha-galactosidase A (a-Gal or GLA, EC 3.2.1.22; UniProt P06280) (Brady et al., 1967; Kint, 1970) and results in lysosomal accumulations of globotriaosylceramide (Gb3), and other neutral glycosphingolipids in various cells and tissues including skin, eye, kidney, heart, brain, and peripheral nervous system (Zarate and Hopkin, 2008).