Most importantly, adoptive transfer of OT-II cells did not alter the frequency of CD206+ TAMs nor their CD206 surface expression levels in OVA negative tumors (Figures 5C,D), suggesting that the degree of tumor infiltration by tumor antigen-specific CD4+ T cells as well as M1 polarization of TAMs might depend on cognate interaction with CD4+ T cells. Here, MRC1 is linked to neoplasm.