MAPT and Parkinson disease: Importantly, by isolating exosomes from CSF derived from two non-PD subjects, we observed that that four out of the six lncRNAs SNCA-AS1, MAPT-AS1, AK127687 and AX747125, could be detected in CSF-derived exosomes, as compared to the control samples (cDNAs prepared without reverse transcriptase) (Figure 5B,C).