In particular, neuroimaging studies in humans have found that PD patients have altered cerebellar activation during motor execution, motor learning and at rest (Wu and Hallett, 2013) In contrast to the SN, where SNCA-rich Lewy bodies are the main histopathological hallmark of the disease, no Lewy bodies are detected in the cerebellum of PD patients and some studies have reported decreased cerebellar SNCA mRNA levels (Fuchs et al., 2008). The gene discussed is SNCA; the disease is Parkinson disease.