GBA1 and Parkinson disease: For GBA1 in particular, genetic evidence has linked heterozygous GBA1 mutations with PD, which in some populations, represent the strongest risk factor for PD, while an association of tagging SNPs within SCARB2, the gene encoding for the lysosomal membrane protein LIMP2 (responsible for the intra-lysosomal transport of GCase) with PD, has been also reported (Michelakakis et al., 2012).