The present study was aimed (Varatharaj and Galea, 2017) to manifest whether inhibition of Omi/HtrA2 by RNA interference or UCF-101 treatment could improve BBB disruption induced by sepsis in vitro; (Banks, 2005) if so, to probe the mechanisms by which Omi/HtrA2 induces BBB dysfunction and septic encephalopathy. Here, HTRA2 is linked to Sepsis.