Henceforth, a detailed study of NCALD function in the pathophysiology of schizophrenia, autism, depression, stress-related disorders like bipolar disorder and anxiety, as well as a comprehensive analysis cognitive behavior of NcaldKO/KO animals have a potential to reveal a disease mouse model for neurodevelopmental disorders with subtle behavioral symptoms, thereby improving our understanding of such disorders. The gene discussed is NCALD; the disease is Anxiety.