In contrast to the high vulnerability of hippocampal calbindin-positive neurons in the human AD brain and its animal models, calretinin-positive fibers in proximity of Abeta plaques were shown to be less affected by dystrophic morphology than neurites containing neurofilament-triplet proteins in Tg2576 and APPswe/PS1dE9 mice and human AD affected brains (Mitew et al., 2013). This evidence concerns the gene CALB1 and Alzheimer disease.