In previous GWAS, variants of the CDH18 gene were found to be associated with leprosy (Liu et al. 2015), age-related hearing impairment (Fransen et al. 2015), blood pressure-related traits in African-Americans (Liang et al. 2017) and with obesity in adult survivors of childhood cancer (Wilson et al. 2015). This evidence concerns the gene CDH18 and obesity due to melanocortin 4 receptor deficiency.