APOE and early-onset autosomal dominant Alzheimer disease: In our previous studies (Wang et al., 2011; Shi et al., 2014), we proposed a novel multivariate measure of hippocampal morphometry to analyze the hippocampal surface deformations related to APOE-e4 dose effects and validated it on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset (adni.loni.usc.edu) with known APOE genotypes (167 subjects with AD, 354 subjects with MCI, and 204 cognitively unimpaired subjects).