In an early study involving 11 cognitively normal APOE-e4 homozygotes (HM) and 22 APOE-e4 non-carriers (NC) with a reported family history of AD who were matched for sex, age, and level of education, Rieman et al. (1998) reported that the HM showed nonsignificant trends for smaller left and right hippocampal volumes. The gene discussed is APOE; the disease is Alzheimer disease.