The pathogenesis of EDS has been linked to genetic mutation which can be categorized into classical (mutation in COL5A1 or COL5A2 gene), hypermobility (mutation in TNXB gene), vascular (mutations in COL3A1 gene), kyphoscoliosis (mutation in PLOD1 gene), dermatosparaxis (mutations in ADAMTS2 gene), and arthrochalasia type (mutations in COL1A1 or COL1A2 gene) [24]. Here, COL5A1 is linked to Kyphoscoliosis.