Lim WK et al reported that out of the 98 FA samples sequenced, 41 (42%) had point mutations in codon 44 of MED12 (20 p.Gly44Asp, 12 p.Gly44Ser, 3 p.Gly44Arg, 3 p.Gly44Val, 2 p.Gly44Cys, and 1 p.Gly44Ala).17 Tan J et al reported that frequent mutations of MED12 were identified in all subtypes of FAs.19 In our study, we identified recurrent somatic mutations of MED12 in 6 cases (6/12, 50%), with 83% of mutations occurring in codon 44 (5/6), emphasizing the importance of these mutations in FA tumorigenesis. Here, MED12 is linked to Friedreich ataxia.