BDNF and Anxiety: We found that 1) normalizing PFC corticosterone signaling in the early-weaned mice ameliorated their anxiety in the plus maze test, indicating that their anxiety-related behavior is caused by heightened HPA activity affecting the PFC, 2) corticosterone was the molecule mediating early weaning’s effects, 3) early-weaned mice exhibited prolonged depression of PFC BDNF synthesis and BDNF exon III mRNA levels.