Because similar effects were observed in the single gene model (mBACtgDyrk1a) and partial trisomy model (Dp(16)1Yey), we propose that DYRK1A overexpression is the main cause of GABAergic over accumulation in DS models and of alteration of the ratio VGAT1/VGLUT1. This evidence concerns the gene SLC17A7 and Dravet syndrome.