However it has been recently proposed that heterozygous disruption of DYRK1A causes a distinctive clinical syndrome, MRD7, that is characterized by the presence of mild to severe ID, microcephaly, intrauterine growth retardation, facial dimorphisms, impaired motor functions and behavioural problems associated to one form of autism61. The gene discussed is DYRK1A; the disease is DYRK1A-related intellectual disability syndrome.