APOE and Alzheimer disease: Since gender matters in AD (women with APOE4 are more likely to develop AD than men with the same allele)33 and since our population of control patients was deficient in women and in APOE4 allele carriers (Supplementary Table 1), we did similar analyze of ApoE fragment/Aβ heteromers restricted to the patients with AD (55.6% women and 55.6% APOE4).