We analyzed RNA-seq data from skin biopsies of healthy and SSc patients obtained from a previously published study18 and confirmed highly upregulated mRNA DR4 and DR5 along with other fibrogenic components, including ACTA2, Col1a2, TGF-β1, and PDGFR-β, in skin from patients with SSc (Fig. 1a). The gene discussed is ACTA2; the disease is systemic sclerosis.