Taken together, the findings of the constructed regulatory network in conjunction with the transcriptional and non-transcriptional genes identified as being regulated by telmisartan indicate that the AGTR1-mediated angiotensin pathway interacted with the PPAR-NFκB signaling pathway, and that the NAFLD pathway was down-regulated through PPARα, PPARδ, and RELA as transcriptional regulators to ameliorate NASH in STAM mice. This evidence concerns the gene PPARD and metabolic dysfunction-associated steatotic liver disease.