Activation of Elk-1 by Dr-Trks was tested in several different cell types: PC6-3 pheochromocytoma (derived from a peripheral nervous system tumor), epithelial HeLa cells, SH-SY5Y neuroblastoma, and NIH3T3 fibroblasts. Here, ELK1 is linked to hereditary pheochromocytoma-paraganglioma.