The 48 h coculture initiates a pro-tumor phenotype skewing of MΦ, indicated by downregulation of IL1B, IL12, CCL18, CD80, as well as CD163, and upregulation of CLEC7A (dectin-1), CD86, CD206, and HLA-DR (Supplementary Fig. 1a, b). Here, IL1B is linked to neoplasm.