In mice harboring Ag104Ld fibrosarcoma cells that are resistant to immune checkpoint inhibitor32, treatment with ANF/anti-PD-L1 antibody significantly inhibited tumor growth (Supplementary Fig. 5a) and increased infiltration of CD8+ and CD3+ T lymphocytes into the tumors (Supplementary Fig. 5b). The gene discussed is CD274; the disease is neoplasm.