To examine the transcriptional differences between inv(16) AML patients expressing CBFβ-MYH11 and normal hematopoietic cell types, we used RNA-seq and compared global gene expression levels between AML blasts and normal CD34+ progenitor cells (CD34), megakaryocytes (Mega), erythrocytes (Ery), and monocytes (Mono). Here, CD34 is linked to acute myeloid leukemia.