The established system contains dox-inducible CBFβ-MYH11 (Fig. 3a, b) and we expressed the oncoprotein during differentiation towards the granulocytic, monocytic, and megakaryocyte lineage (Fig. 3c), allowing the investigation of the effects of CBFβ-MYH11 in the absence of additional leukemia driver mutations. The gene discussed is CBFB; the disease is leukemia.