In analogy to idea that cells involved in entosis have a ‘winner’ or ‘loser’ status based on cell deformability [15], entosis could therefore cause selection for those ‘winner’ tumour cells that have acquired mutations in Myc, KRAS, CDKN2A or Tp53 and lead to heterogeneity that is seen within many tumours. This evidence concerns the gene KRAS and neoplasm.