In analogy to idea that cells involved in entosis have a ‘winner’ or ‘loser’ status based on cell deformability [15], entosis could therefore cause selection for those ‘winner’ tumour cells that have acquired mutations in Myc, KRAS, CDKN2A or Tp53 and lead to heterogeneity that is seen within many tumours. The gene discussed is TP53; the disease is neoplasm.