Intriguingly, melanoma cell line-derived DTPs displayed a similar transcriptomic trajectory to MAPK-independent populations suggesting converging phenotypes as well as other notable characteristics: morphological flattening alongside a proposed mesenchymal-angiogenic switch, initial increases in β-galactosidase as a sign of senescence and heterochromatin formation, and lastly enrichment of inflammatory and IFN pathway signalling [13]. Here, IFNA1 is linked to melanoma.