TFE3-fusion associated RCC is defined by several different translocations involving chromosome Xp11.2, including ASPL, PRCC, NonO, CLTC, SFPQ1, LUC7L3, KHSRP, PARP14, DVL2, and RBM10, as well as unknown genes on chromosome 10 [3–8]. Here, TFE3 is linked to renal cell adenocarcinoma.