Interestingly, high level of TSH itself may be an important risk factor points to the pathogenesis of NAFLD, independent of thyroid hormones [168, 169], and the supplementation of levothyroxine shows clear benefits on NAFLD in subclinical- and mild subclinical- hypothyroidism patients with dyslipidemia [170]. The gene discussed is TG; the disease is metabolic dysfunction-associated steatotic liver disease.