For instance, S1 directs Src and PI3K-mediated TRα translocation from the cytoplasm to the nucleus and promotes expression of target genes, such as hypoxia-inducible factor-1α (HIF-1α) while S2 activates MAPK1 and MAPK2, leading to nuclear trafficking of TRβ1 from the cytoplasm and tumor cell proliferation [58, 60]. The gene discussed is MAPK1; the disease is neoplasm.