IL17A and osteosarcoma: For the purple module, which was mainly related with microtubule bundle formation, drug metabolism-cytochrome P450, and IL-17 signaling pathway and was identified to be negatively correlated with the trait of osteosarcoma, while being positively correlated with the trait of metastasis in osteosarcoma, previous studies have reported that increase of microtubule destabilization was related with G1/G2 phase cell cycle arrest and apoptosis, and microtubule inhibitors could trigger autophagy and cell death in osteosarcoma cell line [10].