Other circulating methylation markers include SESN3 [82], WIF1, and NPY [85] for localized colorectal cancer, RAS [86], PTK2, WIF1, and NPY [85] for metastatic colorectal cancer, TAC1 [87] promoter for esophageal adenocarcinoma, RASSF1A [81] for thyroid cancer, SEPT9 [88] for hepatocellular carcinoma, and SHOX2 and SEPT9 [89] for head and neck squamous cell carcinomas. The gene discussed is SEPTIN9; the disease is metastatic colorectal cancer.