Registry data show a significant association between sex and primary cancer location (p < 0.001), with a prevalence of proximal cancer (including GEJ) in M, as well as a significant association between sex and ADK histotype (p < 0.05), with a prevalence of DGC in F. HER-2 gene amplification was detected in 26% of cases (data consistent with literature). This evidence concerns the gene ERBB2 and cancer.