BRCA1 and breast carcinoma: SBS3 was also generated in the ovarian (OVCAR-8) and breast (HCC38) cancer cell lines (Figure 3), which have attenuated BRCA1 expression due to promoter methylation as well as in lung adenocarcinoma (NCI-H650) and breast cancer (AU565) cell lines, which did not show obvious deficiencies in BRCA1 or BRCA2 function (Figure S2; Table S4).