VWF and platelet-type von Willebrand disease: Importantly, enhanced VWF binding to platelets—as seen in von Willebrand disease (VWD) type 2B - was shown to induce phagocytosis of VWF/platelet complexes by macrophages in the liver and spleen and promote thrombocytopathy by inhibition of platelet integrin αIIbβ3, the platelet fibrinogen receptor [20, 21].