In addition, when analyzing the ATP2B4 association studies with cerebral malaria and severe malaria anemia in African, Asian and Oceanian populations, the Malaria Genomic Epidemiology Network [44] noted that the effect of the ATP2B4 ancestral allele rs10900585-G on malaria might be heterogeneous across phenotypes and/or populations. This evidence concerns the gene ATP2B4 and anemia (phenotype).